Type 1 Diabetes is an autoimmune disease that is triggered by an attack of the immune system. A part of these attacks is likely to be caused by viruses, against which researchers from Sweden and Finland now have a vaccine made.
Of six different strains of the Coxsackie B virus family, the colds and less heart muscle or brain skin inflammations cause, it is believed that they are also involved in the pathogenesis of type 1 Diabetes. Against these six strains, has now produced a vaccine, the mice protects against a virus-induced type 1 Diabetes. This, the scientists report in the journal "Science Advances".
The researchers tested the vaccine in rhesus monkeys are similar to humans. The vaccine was also good and a production of antibodies against the Coxsackie viruses. The scientists consider this as a sign that the vaccine protects against the viruses.
If the vaccine is in early clinical trials as safe, it should be used in children, whose risk for type 1 Diabetes is hereditary conditionally increased. If the disease occurs among the vaccinated children less frequently or not at all, then it would be confirmed that Coxsackie viruses are a causative environmental factor. Prof. Dr. Malin Flodström-Tullberg from the Karolinska Institute said: "It would be fantastic if we could prevent the cases of type 1 Diabetes, of which we suspect to be caused by Coxsackie-virus, even if their exact number is difficult to estimate. At the same time, the vaccine would offer protection against some colds and inflammation of the heart muscle."