Ibuprofen is one of the most popular and commonly used pain relievers. It is available without prescription and is used against numerous ailments. Is unthinkingly dealing with the pain means? An international research team uncovered recently, previously unknown side effects during long-term use. Apparently, the drug brings the male hormone production out of balance and increases the risk for impotence, and depression.
An international research team noted recently, in a study that Ibuprofen can affect a taking about 14 days in addition to negative on the male hormone balance. The researchers suggest, is stimulated during long-term use with high doses, the production of the reproductive hormone Lutropin. This, in turn, affects the production of the sex hormone testosterone, which can lead to the potency disorders, and Depression. The results of the study were recently PNAS in the journal “– Proceedings of the National Academy of Sciences“ published.
In the study administered the research were 31 healthy men who were between 18 and 35 years old, two times daily in a dose of 600 milligrams of Ibuprofen over a period of six weeks. During this time, the subjects were examined regularly by a physician, and their hormone levels measured.
The researchers found after a two-week intake of the subjects that Ibuprofen inhibits the production of testosterone. The body responded with an increased production of the luteinizing hormone (LH), which can be testosterone levels to increase again. After two weeks, the LH levels of the subjects rose to 23 percent. After 44 days, the level was increased to 33 percent.
The increased LH production represents for the body to be a burden, and in medicine as a hormone disorder known, arises more often in older men. This condition is called hypogonadism and is often associated with potency disorders, physical disorders and depression.
The effect could only be in the case of a high-dose long-term use found. Occasional use for acute pain is to be expected, the study results suggest that as a side effect. (vb)