Lymphocyte-to-CRP Ratio May Predict CAD Severity

The study covered in this summary was published on as a preprint and has not yet been peer-reviewed.

Key Takeaways

  • The lymphocyte-to-C-reactive protein ratio (LCR) is a new systemic immune inflammation index that might aid in the early screening and assessment of coronary artery disease (CAD) severity.

  • Lower LCRs are a risk factor for severe CAD.

Why This Matters

  • To date, the relation between LCR and the development and severity of CAD is unclear.

  • This study demonstrates a correlation between LCR and CAD as a potential predictive and protective factor for the occurrence and severity of disease.

Study Design

  • The study involved 1107 patients 55 to 70 years of age (median age, 64 years; 66% male) who underwent concurrent coronary angiography from January 2019 to December 2021.

  • Key exclusion criteria were a previous myocardial infarction, coronary intervention therapy, or coronary artery bypass grafting; acute cerebral infarction occurring within 6 months; other heart diseases, such as congenital heart disease, valvular heart disease, and great vascular disease; cancer and infectious diseases.

  • Each patient underwent Judkins-style coronary angiography, and the Gensini score was used to determine the severity of coronary stenosis.

  • Venous blood was collected from patients after 10 to 12 hours of fasting.

  • Propensity-score matching (PSM) was used to balance the clinical baseline data of those with and without CAD, and a logistic regression model was used to analyze the relation between LCR and CAD.

Key Results

  • Gender, smoking history, hypertension, diabetes, and age were significantly different between the two groups prior to PSM, with no statistically significant difference after PSM.

  • LCR was significantly lower in patients with than without CAD (0.96 vs 1.34; P = .003) and in those with severe rather than mild CAD (0.7 vs 1.17; P < .001).

  • LCR was an independent related protective factor against severe CAD lesions (odds ratio [OR], 0.54).

  • The neutrophils-to-lymphocytes ratio (OR, 1.86) and platelet-to-lymphocyte ratio (OR, 2.29) were independent related risk factors for CAD severity.


  • The results of this study are applicable to a narrow population, as only patients diagnosed with initial CAD were included.

  • LCR levels of patients were not regularly assessed and the long-term effect of LCR was not evaluated.

  • This was a single-center study with a small number of patients.


  • This work was supported by the Natural Science Foundation of Jiangsu Province, the Major Project of Jiangsu Provincial Health Commission, and the Wuxi Science and Technology Development Fund.

  • The authors disclosed no competing interests.

This is a summary of a preprint research study, Relationship between lymphocyte to C-reactive protein ratio and severity of coronary artery disease, written by Ke Chen from the Wuxi Clinical College of Anhui Medical University and colleagues on and provided to you by Medscape. This study has not yet been peer-reviewed. The full text of the study can be found on

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