The cancer therapy known as CAR-T has revolutionized treatment of some blood cancers since it was introduced in 2017. The therapy uses genetically altered immune cells to home in on cancer cells and destroy them. Now, studying mice with an autoimmune disease similar to multiple sclerosis (MS), researchers at Washington University School of Medicine in
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Challenge 1: Lack of prominent cellular and molecular pathways for pharmaceutical targetsChallenge 2: lack of proper animal models to evaluate therapeutic approachesChallenge 3: Difficulties associated with the development of clinical trialsPotential solutionsReferencesFurther reading Huntington's disease (HD) is a neurodegenerative genetic disorder prevalent in around 5 to 10 per 100,000 individuals in North America and Western
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IntroductionPeriod ShamingMedicalizing or Ignoring Period SymptomsPreventing AcceptanceDemonizing Natural ProcessesIgnoring Menstrual NeedsOvercoming period stigmaRecognizing NormalcySocial ProgrammingImproved Sanitary FacilitiesConclusionReferencesFurther Reading Menstruation is a completely natural and universal phenomenon, associated with normal female reproduction. However, it is surrounded by negative perceptions, and communication about it, when it occurs, is typically limited to its pain, inconvenience and embarrassment. From
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IntroductionThe concept of eradicationChallengesReferencesFurther reading Eradicating a disease has proven challenging for a variety of reasons, not least of all it has been difficult to conceptualize and define what exactly eradication of disease really means. This article considers some of the factors that currently pose a challenge to the notion of disease eradication with a
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What is a heart attack?What are the treatment options for a heart attack?How to recover from a heart attackCardiac rehabilitationMedicationsReferences Further reading Heart attack, also known as myocardial infarction, occurs when the blood supply to the heart is blocked suddenly. The condition can be fatal if left untreated. Timely recovery of normal activity is possible after
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Key breath metabolitesCommon techniques associated with breath analysisCollection and analysis of stored breath samplesDiagnosis of disease using volatile biomarkersCommercial production of breath analyzers for disease detectionReferences Further reading Breath is an important matrix for analyzing volatile organic compounds (VOCs) that are generated within the body. These compounds travel through the blood in the body, reach the
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IntroductionWhat is dementia?Symptoms of DementiaTen myths and misconceptions about dementiaReferences People worry that they or someone close will get dementia when they get older. But what is dementia, and does it even exist? This article will look at what dementia is before examining ten common misconceptions associated with the disease. Image Credit: Salim Hanzaz/Shutterstock.com What is
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IntroductionWhat are antibiotics?History of antibioticsCommencement of the antibiotic eraFirst clinical use of antibioticsThe golden age of antibiotic discoveryDevelopments in antibiotic discovery ReferencesFurther reading Antibiotics are medicines used to treat bacterial infections. Traces of antibiotics were found in human skeletons from ancient times dating back to 350 – 550 CE. In the ancient Egyptian era, molds
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IntroductionCauses and symptomsEpidemiologyDiagnosisTreatment and managementReferencesFurther reading Zellweger spectrum disorders (ZSDs) are a group of rare genetic diseases marked by a lack of functional peroxisomes caused by mutations in various PEX genes. Zellweger spectrum diseases are a subset of peroxisome biogenesis disorders that span a clinical spectrum of severity from severe to lesser phenotypes. Several metabolite
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IntroductionWhy HIV/AIDS Costs are Difficult to AscertainDrug Designs That Have Buffered the Economic Impact of HIV/AIDSHow has HIV/AIDS Affected the MarketHow we can Presently Avert the Economic Hardships of HIV/AIDSReferences AIDS has been placing stress on the world economy since the early 90s, whether it be government, the private sector, or individual households. With the
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