Vanderbilt University engineering researchers took a major step toward building a “brain in a dish:” They cultured induced pluripotent stem cells into a successful three-dimensional blood-brain barrier model. The future of drug testing and disease research lies in creating organoids, or models of human organs, to determine efficacy and potency of medications. Duplicating the endothelial
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Similar to leaky pipes, veins, as they return blood to the heart, sometimes fail to close completely. They stretch out and subsequently leak near the surface of the skin, creating spider or varicose veins that may cause discomfort. Dr. Tanya Flohr, a vascular surgeon at Penn State Heart and Vascular Institute, said the majority of
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Acute kidney injury (AKI), an abrupt or rapid decline in kidney function, is an increasingly prevalent and potentially serious condition that often arises due to certain health problems or medical treatments that deprive the kidneys of normal blood flow or damage kidney tissue. A new study appearing in an upcoming issue of the Journal of
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(HealthDay)—In sedentary overweight/obese older adults, morning exercise reduces systolic blood pressure, with additional benefit seen by combining exercise with regular breaks in sitting, according to a study published online Feb. 20 in Hypertension. Michael J. Wheeler, from the University of Western Australia in Perth, and colleagues examined whether there is an additive hypotensive effect when
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(HealthDay)—A deep learning-enhanced device can accurately detect diabetic retinopathy (DR), according to a study published online Feb. 14 in Diabetes Care. For people with type 2 diabetes visiting a primary care screening program, Frank D. Verbraak, from the VU Medical Center in Amsterdam, and colleagues graded retinal images via a hybrid deep learning-enhanced device. Its
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Researchers from Texas A&M University, led by Dr. Akhilesh K. Gaharwar, have developed a new way to deliver treatment for cartilage regeneration. Gaharwar, assistant professor in the Department of Biomedical Engineering at Texas A&M, said the nanoclay-based platform for sustained and prolonged delivery of protein therapeutics has the potential to impact treating osteoarthritis, a degenerative
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Clinicians should consider using PCSK9 inhibitors to lower cholesterol in patients with statin-associated autoimmune myopathy. Findings from a case report are published in the Annals of Internal Medicine. Beyond its toxic effect, statin use has been associated with a rare but potentially severe and disabling type of muscle disease known as statin-associated autoimmune myopathy. Its
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Directly activating a gene important to exciting our excitatory neurons and associated with major depression may help turn around classic symptoms like social isolation and loss of interest, at least for males, scientists report. They looked in the prefrontal cortex, a brain area involved in complex behaviors like planning, personality and social behavior and known
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How can we best help Australians who are at risk of developing a mental health disorder? A new recommendation to expand the Better Access initiative would open up government-subsidised psychological care to this effect. The recommendation is one of 14 put forward by the Mental Health Reference Group, part of the Medicare Benefits Schedule Review
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Researchers from Cardiff University have established a link between a genetic mutation and developmental movement impairments in autism. The study, which found that the mutation of the CYFIP1 gene leads to changes in the development of brain cells, leading to the motor issues, also suggests that motor learning difficulties occur at a young age and
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